After GLP-1 Weight Loss, What Comes Next? A New Approach to Volume Restoration

28 million Americans are currently on GLP-1 medications.

And many of them are discovering something unexpected: Weight loss doesn't always mean looking better. Sometimes it means looking... different. Older. Deflated.

"Ozempic face" is real. So is the loss of breast volume, the flattening of contours, the skin that suddenly has nothing to support it. It's biology.

And it's addressable.

At our practice, we specialize in post-GLP-1 restoration-helping patients complete their transformation in a way that matches how they feel inside. Including options you won't find almost anywhere else.

Weight loss changes everything- including things you didn't expect.

If you're among the 28 million Americans currently taking GLP-1 medications like Ozempic, Wegovy, or Mounjaro, you've likely experienced the benefits: sustainable weight loss, improved metabolic health, and a renewed relationship with food. But you may have also noticed something else. Your face looks different. Your skin seems looser. Areas that once had natural fullness now appear deflated. This isn't your imagination. And you're not alone.

The GLP-1 Effect on Volume

Rapid or significant weight loss-regardless of how it's achieved-reduces fat volume throughout the body. While this is often the goal, fat loss doesn't discriminate. It affects areas where you want to lose volume and areas where that volume was actually serving you.

The face loses its natural padding, leading to what's colloquially known as "Ozempic face"—a gaunt, aged appearance characterized by hollowed cheeks, prominent nasolabial folds, and loose skin around the jawline.

The body experiences similar changes. Breast volume decreases. The buttocks flatten. Skin that once stretched over fat deposits now has nothing to support it.

For many patients, this creates a frustrating paradox: you've achieved your weight loss goals, but you don't feel like you look better. Just... different. And not necessarily in the way you hoped.

Why Traditional Solutions Fall Short

The aesthetic medicine field has scrambled to address GLP-1-related volume loss, and the standard recommendations often include:

• Dermal fillers for facial volume (temporary, requires ongoing maintenance)

• Fat transfer for body contouring (requires liposuction, which may not be ideal for GLP-1 patients with limited fat stores)

• Implants for breast or buttock augmentation (surgical, with associated risks and recovery)

These options work for some patients. But for many—especially those who are new to aesthetic procedures or want something more natural—they don't quite fit.

Enter AlloClae: Regenerative Volume Restoration

At our practice, we've been working with a different approach: AlloClae, a regenerative matrix derived from donated human tissue.

Here's how it works:

AlloClae starts with donated tissue, which undergoes a process called decellularization. This removes all cellular material—the DNA, the nucleus, everything that made it someone else's tissue—while preserving the extracellular matrix. Think of it as keeping the scaffolding while removing everything else.

When this matrix is injected into your body, something remarkable happens: your own tissue grows into that space. Your cells recognize the structure and populate it, essentially rebuilding volume with your own biology.

The result isn't a foreign substance sitting in your body. It's you.

Why This Matters for GLP-1 Patients

For patients experiencing post-GLP-1 volume loss, AlloClae offers several distinct advantages:

1. Natural integration. Because your own tissue grows into the matrix, results look and feel natural—not "done."

2. Versatility. AlloClae can be used for facial volumization, breast augmentation (up to a 3/4 cup increase is possible), and buttock enhancement, addressing multiple concerns from a single technology.

3. Ideal for aesthetic newcomers. Many GLP-1 patients have never had aesthetic procedures before. AlloClae offers a less intimidating entry point than surgery or implants.

4. Complementary to other treatments. AlloClae works alongside treatments like Sculptra and hyaluronic acid fillers, which provide skin thickening and hydration. A comprehensive protocol often combines multiple approaches.

Limited Availability—By Design

We're one of very few practices in the country currently offering AlloClae. This isn't a marketing gimmick—it's reality. The technology is new, demand far exceeds supply, and not every practice has the expertise to work with regenerative matrices.

Dr. Lorenc has been researching and developing protocols for this approach for over three years. That investment in understanding the science—not just the technique—is what allows us to offer it with confidence.

What's Next: DermaClae for Facial Rejuvenation

Looking ahead, we're anticipating the release of DermaClae in 2025—a smaller-particle version of this technology specifically designed for facial injection. This will allow for more precise facial volumization and rejuvenation, expanding what's possible with regenerative approaches.

Is AlloClae Right for You?

AlloClae isn't for everyone. The best candidates are those who:

• Have experienced volume loss due to GLP-1 medications or other weight loss

• Want natural-looking, natural-feeling results

• Prefer to avoid synthetic implants or extensive surgery

• Are looking for breast, buttock, or facial volumization

• Understand that this is a newer technology with limited availability

  
  

If this sounds like you, we invite you to schedule a consultation. We'll assess your concerns, discuss your goals, and determine whether AlloClae—alone or in combination with other treatments—is the right approach for your journey.

Because your weight loss story doesn't have to end with compromise. It can end with restoration.